Fig. 6 | Hypertension Research

Fig. 6

From: Effect of a novel nonsteroidal selective mineralocorticoid receptor antagonist, esaxerenone (CS-3150), on blood pressure and renal injury in high salt-treated type 2 diabetic mice

Fig. 6

Effects of esaxerenone (EXR) and spironolactone (SPL) on renal oxidative stress. Representative images of dihydroethidium (DHE) immunofluorescence staining (original magnification, ×200) (a). DHE fluorescence intensity (b). NADPH oxidase activity in homogenized renal cortical tissues (c). Renal cortical tissue gp91phox (d), and p22phox (e) mRNA levels were determined by real-time reverse transcription-polymerase chain reaction. All mRNA data are expressed as the relative difference to the C57BL/6 + NS group, after normalization for β-actin expression. NS, normal salt diet; HS, high salt diet; C57BL/6, C57BL/6 mice; KK-Ay, KK-Ay mice. aP < 0.05 vs. KK-Ay + HS

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