Fig. 1 | Hypertension Research

Fig. 1

From: Treatment of renal congestion by tolvaptan

Fig. 1

Hypothesis for renal congestion and tolvaptan treatment. Congestive heart failure induces central/renal venous congestion and increases renal interstitial hydrostatic pressure (RIHP). The increase in RIHP reduces medullary blood flow (MBF) by increasing the resistance and venous impedance indices. The reduction of MBF results in renal ischemia and Na retention. In contrast, treatment with tolvaptan improves heart failure and reduces central/renal venous congestion and RIHP. The reduction of RIHP improves the resistance and venous impedance indices and MBF, which could improve renal protection and Na excretion

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