Table 4 Mediation of CRP and leptin on the relation between PBF and BP

From: Sex difference in the mediation roles of an inflammatory factor (hsCRP) and adipokines on the relationship between adiposity and blood pressure

Sex

X

M

Y

Direct association

Indirect association

% mediation

% direct association

β (95% CI)

P

β (95% CI)

P

Male

PBF

Leptin

SBP

0.202 (0.081–0.324)

0.001

0.059 (0.005–0.112)

0.031

22.5

77.5

 

DBP

0.063 (0.026–0.273)

0.018

0.068 (0.014–0.123)

0.014

31.4

68.6

Female

CRP

SBP

0.135 (0.062–0.208)

<0.001

0.058 (0.027–0.090)

<0.001

30.2

69.8

 

DBP

0.151 (0.077–0.225)

<0.001

0.063 (0.031–0.095)

<0.001

29.5

70.5

  1. PBF percentage of body fat, SBP systolic blood pressure, DBP diastolic blood pressure, CRP C-reaction protein, c′ direct association between the independent variable (X = PBF) and the outcome variable (Y = SBP/DBP) was determined, a × b indirect association between X and Y through the proposed mediator, % mediation percentage mediation of the potential mediator (a × b/c)
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