Fig. 6 | Hypertension Research

Fig. 6

From: Acute salt loading induces sympathetic nervous system overdrive in mice lacking salt-inducible kinase 1 (SIK1)

Fig. 6

Effect of 50 mg/kg/day etamicastat (ETA) treatment on blood pressure, heart rate and home-cage activity in telemetered salt-inducible kinase 1 (SIK1) knockout (sik1−/−) mice challenged with a high-salt (8% NaCl) diet. ETA treatment for 14 days, in which in the last 7 days, animals were fed a high-salt diet. a Systolic blood pressure (SBP), (b) diastolic blood pressure (DBP), (c) mean arterial pressure (MAP), (d) heart rate (HR) and (e) home-cage activity. Mean ± SEM; n = 5 to 6 per group; values were determined to be significantly different from high-salt diet group (*P < 0.05) by unpaired t-test

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