Table 4 Tissue catecholamines levels after one week of 50 mg/kg/day etamicastat (ETA) treatment in sik1−/− mice on an 8% NaCl intake

From: Acute salt loading induces sympathetic nervous system overdrive in mice lacking salt-inducible kinase 1 (SIK1)

 

8% NaCl diet

ETA + 8% NaCl diet

Kidney

  Noradrenaline

2437 ± 169

1136 ± 98*

  Dopamine

408 ± 29

1169 ± 72*

Ventricles

  Noradrenaline

3723 ± 224

1736 ± 224*

  Dopamine

298 ± 30

1672 ± 178*

Atria

  Noradrenaline

8913 ± 987

2484 ± 187*

  Dopamine

898 ± 126

2500 ± 98*

Aorta

  Noradrenaline

7315 ± 1431

3209 ± 444*

  Dopamine

968 ± 186

5707 ± 340*

  1. All = pmol/g tissue. Mean ± SEM, n = 7 per group. *P < 0.05 as compared with 8% NaCl diet group
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