Table 3 Multivariate Cox analysis. Baseline variables independently associated with the conversion of resistant hypertension into refractory hypertension over the course of the follow-up

From: Factors associated with the changes from a resistant to a refractory phenotype in hypertensive patients: a Pragmatic Longitudinal Study

Variable

B

ET

OR (95% CI)

p

Years since diagnosis of RH

0.06

0.021

1.06 (1.02–1.1)

0.007

HbA1c*

0.34

0.12

1.42 (1.11–1.8)

0.005

Heart rate (bpm)**

0.047

0.02

1.05 (1.01–1.09)

0.019

Poor adherence to CPAP or lack of prescription

1.21

0.42

3.36 (1.47–7.7)

0.004

Antecedents of dyslipidemia

0.74

0.44

2.01 (0.88–4.96)

0.092

  1. *The HbA1c values refer to those recorded at the start of the study
  2. **The values for heart rate (bmp) and 24 h systolic blood pressure refer to those recorded at the initial 24 h-ABPM
  3. RH resistant hypertension, OR odds ratio, CPAP continuous positive airway pressure, HbA1c glycated hemoglobin
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