Fig. 5 | Hypertension Research

Fig. 5

From: TRPP2 associates with STIM1 to regulate cerebral vasoconstriction and enhance high salt intake-induced hypertensive cerebrovascular spasm

Fig. 5

Functional roles of TRPP2, STIM1, and Orai3 in the store-operated calcium entry (SOCE)-induced contraction of rat cerebral basilar arteries. Representative images of TRPP2 and STIM1 expression in cerebral basilar arteries pretreated with scrambled siRNA (control), TRPP2-specific siRNA (a), or STIM1-specific siRNA (b). Summary data showing the effects of pretreatment with TRPP2-specific siRNA (c), STIM1-specific siRNA (d), or 10 μM BTP-2 (e) on SOCE-induced cerebral basilar artery ring contraction. Cerebral basilar artery rings were pretreated with 100 nM endothelin-1 and 1 μM verapamil in a Ca2+-free solution for 10 min. The values are the means ± SE; n = 4–7 samples. *P < 0.05 vs. scrambled siRNA in c and d, and vs. control in e; #P < 0.05 vs. hypertension in e (Mann–Whitney U test (two-tailed))

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