Table 2 Comparison of clinical data between small and large PA lesion groups (outcome cohort)

From: Diverse pathological lesions of primary aldosteronism and their clinical significance

Variables

S-PAL group (n = 26)

n

L-PAL group (n = 87)

n

p values

Statistics

CT, tumor size (mm, threshold: 5 mm)

10.0 (2.5–17.6)

26

15.0 (10.0–17.7)

87

0.097

MW-U

Age (year)

50.0 (43.0–63.0)

27

50.0 (41.0–61.0)

87

0.73

MW-U

Sex (male vs. female)

14 (51.9%) vs 13 (48.1%)

27

44 (50.6%) vs 43 (49.4%)

87

1.0

Fisher

Side of adrenalectomy (left vs. right)

17 (63.0%) vs 10 (37.0%)

27

46 (52.9%) vs 41 (47.1%)

87

0.39

Fisher

Body mass index (kg/m2)

24.4 (22.2–27.7)

27

23.1 (20.3–27.0)

87

0.29

MW-U

eGFR (mL/min/1.73 m2)

83.4 (74.3–96.5)

25

80.7 (68.1–97.5)

86

0.53

MW-U

Systolic blood pressure (mmHg)

138.8 ± 17.8

27

142.1 ± 18.3

85

0.41

uTT

Diastolic blood pressure (mmHg)

87.4 ± 12.7

27

86.7 ± 12.9

85

0.80

uTT

Intensity of antihypertensives

1.33 (1.00–2.17)

27

2.00 (1.00–2.50)

87

0.012

MW-U

Lateralized ratio (LR) in AVS

5.24 (3.16–8.23)

20

14.59 (4.79–31.86)

60

<0.001

MW-U

CYP11B2 positivity

3.26 ± 3.97

27

33.1 ± 12.8

87

<0.001

uTT

Serum K level (mEq/L)

3.61 ± 0.46

27

2.86 ± 0.58

86

<0.001

uTT

PAC (pg/mL)

164.0 (139.0–217.0)

27

320.0 (232.8–517.0)

86

<0.001

MW-U

PRA (ng/mL/hr)

0.200 (0.100–0.300)

27

0.200 (0.100–0.300)

86

0.51

MW-U

  1. When a tumor was not detected on CT and the size of tumor was shorter than 5 mm, the tumor size in statistical analyses was set at 2.5 mm
  2. BP blood pressure, eGFR estimated glomerular filtration rate, PAC plasma aldosterone concentration, PRA plasma renin activity, ARR aldosterone-renin ratio = PAC/PRA, AVS adrenal venous sampling, MW-U the Mann–Whitney U test, the unpaired t-test: uTT, S-PAL group small PA lesion group, L-PAL group large PA lesion group
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