Fig. 4 | Hypertension Research

Fig. 4

From: Effects of an SGLT2 inhibitor on the salt sensitivity of blood pressure and sympathetic nerve activity in a nondiabetic rat model of chronic kidney disease

Fig. 4The alternative text for this image may have been generated using AI.

Impact of luseogliflozin treatment on sympathetic nerve activity (SNA) and circadian rhythm. Low frequency (LF) of systolic blood pressure (SBP) reflects the level of SNA. (a) Average 24-h LF of SBP during feeding with a NSD (0.3% NaCl) or HSD (8% NaCl) and after switching back to a NSD in adenine-induced CKD rats with or without luseogliflozin treatment. *P < 0.05, **P < 0.01, ***P < 0.001 vs. vehicle group; ##P < 0.01 vs. adenine group. Average 12-h LF of SBP in the inactive and active periods (b) during feeding with a NSD, (c) after 5 days of a HSD, and (d) 2 days after switching to a NSD. *P < 0.05, **P < 0.01, ***P < 0.001 vs. the inactive period of the respective group; #P < 0.05, ###P < 0.001 vs. the active period of the vehicle group; †P < 0.05 vs. the active period of the adenine group

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