Fig. 7 | Hypertension Research

Fig. 7

From: Pulmonary arterial hypertension induces the release of circulating extracellular vesicles with oxidative content and alters redox and mitochondrial homeostasis in the brains of rats

Fig. 7

Characterization, oxidative stress markers, and immunocontent of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and sirtuin 1 (Sirt1) in blood-derived circulating extracellular vesicles (EVs) of rats with monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). A Circulating EV size distribution (262 ± 106 nm) and concentration; B graphic and illustrative figure of flotillin-1 (FLOT1) protein expression in EVs; C reactive oxygen species (ROS) levels in EVs; D lipid peroxidation (LPO) levels in EVs; E nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in EVs; F superoxide dismutase (SOD) activity in EVs; G catalase (CAT) activity in EVs; H glutathione peroxidase (GPx) activity in EVs; I graphic and illustrative figure of PGC-1α protein expression in EVs; J graphic and illustrative figure of sirtuin 1 (Sirt1) protein expression in EVs. Data are expressed as the mean ± standard deviation (n = 4). *P < 0.05 vs control; **P < 0.01 vs control; ***P < 0.001 vs control

Back to article page