Fig. 1 | Hypertension Research

Fig. 1

From: Melatonin ameliorates hypertension in hypertensive pregnant mice and suppresses the hypertension-induced decrease in Ca2+-activated K+ channels in uterine arteries

Fig. 1

Maternal melatonin supplementation ameliorated hypertensive phenotypes in the mice with GH. A Systolic blood pressure (SBP) was measured using tail-cuff plethysmography at GD17.5. Maternal melatonin supplementation significantly lowered SBP. Urinary protein levels expressed as mg/day (B) were measured at GD17.5 in pregnant mice of each group. Administration of amlodipine, a calcium channel blocker, significantly reduced SBP (C) and attenuated urinary protein levels (D) in the mice with GH. WT, wild type. Model, mice with GH. 12 mice for each group. Data are presented as the mean ± SD. ***p < 0.001, comparison between the control group of WT and model mice. #p < 0.05, ##p < 0.01, comparison between the drug administration (melatonin or amlodipine) group and the control group of model mice

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