Fig. 4 | Hypertension Research

Fig. 4

From: Rivaroxaban attenuates cardiac hypertrophy by inhibiting protease-activated receptor-2 signaling in renin-overexpressing hypertensive mice

Fig. 4

Effects of Riv on the gene expression of PAR-2 and proinflammatory and profibrotic cytokines in the heart. Gene expression of PAR-2 (A), TNF-α (B), TGF-β1 (C), β-MHC (D), and COL3A1 (E) in Ren-Tg and WT mice (n = 4–6). Comparisons were made by two-way ANOVA followed by Tukey’s post hoc test. Ren-Tg indicates renin-overexpressing hypertensive transgenic, WT wild-type, Riv rivaroxaban, PAR-2 protease-activated receptor-2, TNF-α tumor necrosis factor-α, TGF-β1 transforming growth factor-β1, β-MHC β-myosin heavy chain, COL3A1 collagen type 3 α1, GAPDH glyceraldehyde-3-phosphate dehydrogenase

Back to article page