Fig. 3

Heat maps depicting the 10-year risk of a composite cardiovascular endpoint in relation to 24-h mean arterial pressure (MAP), systolic and diastolic BP in 11,596 IDACO participants. Numbers in the A and B grids represent the percentage of participants within each BP cross-classification category; numbers in C and D represent the 10-year risks. Heat maps were derived by Cox proportional hazards regression with systolic BP (C) or diastolic BP (D) plotted along the vertical axis and MAP along the horizontal axis. Estimates of the 10-year risk were adjusted for cohort (random effect), sex, and baseline characteristics including age, body mass index, smoking and drinking, serum cholesterol, antihypertensive drug intake, history of cardiovascular disease, and diabetes. Higher MAP consistently conferred greater risk (P < 0.001) with an additional contribution of systolic BP (P < 0.001 (C)), whereas higher diastolic BP attenuated the risk (P < 0.001 (D)). Reproduced from reference [62], which was published was an open-access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License