Table 3 Optimal cutoff values of secretion ratios (‰) of aldosterone, 18-hydroxycortisol, and 18-oxocortisol for prediction of unilateral PA (UU) in our cohort (n = 71 with successful AVS)

From: Optimizing adrenal vein sampling in primary aldosteronism subtyping through LC–MS/MS and secretion ratios of aldosterone, 18-oxocortisol, and 18-hydroxycortisol

Diagnosing for

 

AUC (95% CI)

Cutoffs (‰)

Sensitivity (95% CI)

Specificity (95% CI)

 

Pre-ACTH

    

Ipsilateral PA (UU)

Aldosterone

0.86 (0.79–0.93)

>1.664

91.7 (74.2–98.5)

68.2 (58.9–76.3)

18-Oxocortisol

0.92 (0.86–0.98)

>0.785

90.0 (69.9–98.2)

77.2 (68.1–84.3)

18-Hydroxycortisol

0.80 (0.69–0.91)

>9.927

62.5 (42.7–78.8)

90.7 (83.7–94.8)

Contralateral PA (UU)

Aldosterone

0.78 (0.68–0.89)

<0.675

78.3 (58.1–90.3)

75.9 (67.1–83.0)

18-Oxocortisol

0.64 (0.59–0.75)

<0.414

73.9 (53.5–87.5)

54.1 (44.3–63.6)

18-Hydroxycortisol

0.61 (0.47–0.75)

<2.948

43.5 (25.6–63.2)

88.0 (82.5–92.8)

 

Post-ACTH

    

Ipsilateral PA (UU)

Aldosterone

0.89 (0.82–0.96)

>3.352

72.0 (52.4–58.7)

92.0 (85.6–97.8)

18-Oxocortisol

0.88 (0.80–0.95)

>0.611

76.0 (56.6–88.5)

88.5 (81.3–93.2)

18-Hydroxycortisol

0.81 (0.72–0.90)

>4.745

76.0 (56.6–88.5)

75.2 (66.5–82.2)

Contralateral PA (UU)

Aldosterone

0.89 (0.83–0.96)

<0.637

88.0 (70.0–95.8)

85.0 (77.2–90.4)

18-Oxocortisol

0.83 (0.75–0.91)

<0.171

84.0 (60.9–91.1)

76.1 (67.5–83.0)

18-Hydroxycortisol

0.64 (0.50–0.77)

<2.518

44.0 (26.7–62.9)

86.7 (73.3–91.8)

  1. UU presented unilateral results for both unstimulated and stimulated AVS
  2. ACTH adrenocorticotropic hormone, AUC area under the curve, AVS adrenal venous sampling, CI confidence interval, PA primary aldosteronism
Back to article page