Fig. 2 | Hypertension Research

Fig. 2

From: Investigating the cut-off values of captopril challenge test for primary aldosteronism using the novel chemiluminescent enzyme immunoassay method: a retrospective cohort study

Fig. 2

Changes of renin, aldosterone, and its ratio during the CCT. Changes in the plasma renin activity (PRA), plasma aldosterone concentration (PAC), and its ratio (ARR) during the captopril challenge test (CCT). Evaluation of these parameters were performed at baseline and 90 min after 50 mg captopril loading. PACs were measured using the novel chemiluminescent enzyme immunoassay (CLEIA) and radioimmunoassay (RIA, the conventional assay). A PRA changes during the CCT. B PACs at baseline. C PACs after captopril loading. D ARRs at baseline. E ARRs after captopril loading. In (B–E) panel, the symbols used show the participants as follows: black circle, unilateral primary aldosteronism (PA); grey circle, bilateral PA; open circle, essential hypertension; and open circle with a cross, PA patients without laterality identification. The p-values of all comparison using Mann Whitney U test were calculated as < 0.001 (A–E)

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