Table 1 Baseline characteristics of the study participants

From: Investigating the cut-off values of captopril challenge test for primary aldosteronism using the novel chemiluminescent enzyme immunoassay method: a retrospective cohort study

 

PA

EH

P value

 

All

Double positive

Positive only for CCT

Positive only for SIT

 

All PA vs. EH

 

N = 299

N = 196

N = 42

N = 61

N = 39

 

Male (n[%])

129 [43.1%]

94 [48.0%]

12 [28.6%]

23 [37.7%]

9 [23.1%]

0.02

Age (yr)

54 [46,64]

55 [47,64]

57 [53,66]

51 [42,57]

52 [47,64]

0.74

Body weight (kg)

64.6 [55.1, 74.8]

65.6 [55.4, 76.1]

59.6 [51.4, 64.9]

65.2 [55.9, 75.9]

61.0 [54.0, 73.6]

0.41

Body mass index (kg/m2)

24.4 [21.8, 27.0]

24.5 [22.0, 27.1]

23.0 [20.9, 24.9]

25.2 [22.2, 28.2]

25.1 [21.3, 28.0]

0.66

Systolic BP (mmHg)

137 [128, 148]

137 [128, 148]

135 [127, 143]

139 [130, 151]

141 [126, 150]

0.43

Diastolic BP (mmHg)

85 [77,91]

84 [77,90]

84 [77,91]

89 [81,95]

85 [78,95]

0.74

Anti-hypertensive drugs (n)

1 [1,2]

1 [1,2]

1 [1,2]

1 [1, 1]

1 [1,2]

0.76

eGFR (mL/min/1.73 m2)

78.0 [66.9, 91.0]

77.0 [66.0, 90.5]

80.5 [68.0, 91.0]

81.0 [68.5, 92.3]

77.0 [70.0, 91.8]

0.74

Serum potassium (mM)

3.8 [3.6, 4.0]

3.8 [3.5, 4.0]

4.0 [3.7, 4.2]

3.8 [3.7, 4.1]

3.9 [3.8, 4.1]

0.06

Propotion of Potassium replacement (n[%])

200 [66.9%]

150 [76.5%]

13 [31.0%]

37 [60.7%]

20 [51.3%]

0.05

Potassium dosage (mmol/day)

16.0 [0.0, 42.0]

24.0 [7.6, 54.0]

0.0 [0.0, 10.8]

10.8 [0.0, 26.0]

7.2 [0.0, 19.0]

0.02

PAC (ng/dL)

20.4 [15.6, 30.7]

22.7 [17.3, 36.1]

14.1 [12.1, 19.6]

18.6 [14.9, 22.6]

15.1 [12.1, 18.7]

<0.001

PRA (ng/mL/h)

0.20 [0.20, 0.40]

0.20 [0.20, 0.30]

0.20 [0.20, 0.30]

0.60 [0.40, 0.70]

0.50 [0.40, 0.68]

<0.001

ARR (ng/dL per ng/mL/h)

77.5 [45.1, 113.3]

95.8 [69.8, 151.0]

62.0 [45.5, 87.5]

33.8 [24.9, 44.3]

26.3 [22.2, 45.8]

<0.001

Number of PA subtypes (unilateral, bilateral, not specified)

109, 168, 22

102, 88, 6

2, 35, 5

5, 45, 11

-

 
  1. PA Primary aldosteronism, EH Essential hypertension, CCT Captopril challenge test, SIT Saline infusion test, BP Blood pressure, eGFR estimated glomerular function ratio, PAC Plasma aldosterone concentration (measured by the radioimmunoassay), PRA Plasma renin activity, ARR Aldosterone-to-renin ratio
  2. Categorical and continuous variables are shown as number with percentages and median with interquartile range, respectively
  3. Comparison of the variables between PA and EH was performed using Mann-Whitney U test or Chi-square test based on the variable category
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