Table 1 Patients’ baseline characteristics and blood pressure levels
Total | Monotherapy | Dual therapy | |
|---|---|---|---|
N | 1,657 | 867 | 790 |
Age, y | 69.5 ± 9.3 | 69.6 ± 9.2 | 69.5 ± 9.3 |
Female sex | 482 (29.1) | 237 (29.3) | 245 (31.0) |
Asian a | 1,657 (100) | 867 (100) | 790 (100) |
Body mass index, kg/m2 | 23.8 ± 3.5 | 23.7 ± 3.4 | 23.9 ± 3.6 |
Medical history | |||
Hypertension | 1,419 (85.6) | 740 (85.4) | 679 (85.9) |
Dyslipidemia | 935 (56.4) | 501 (57.8) | 434 (54.9) |
Diabetes mellitus | 632 (38.1) | 331 (38.2) | 301 (38.1) |
Chronic kidney disease | 100 (6.0) | 46 (5.3) | 54 (6.8) |
Peripheral arterial disease | 46 (2.8) | 21 (2.4) | 25 (3.2) |
History of ischemic strokeb | 246 (14.8) | 136 (15.7) | 110 (13.9) |
History of ischemic heart disease | 87 (5.3) | 44 (5.1) | 43 (5.4) |
Current smoking | 476 (28.7) | 254 (29.3) | 222 (28.1) |
Intracranial artery stenosis | 493 (29.8) | 256 (29.5) | 237 (30.0) |
Extracranial artery stenosis | 236 (14.2) | 131 (15.1) | 105 (13.3) |
Antihypertensive medication | |||
Calcium channel blockers | 817 (49.3) | 427 (49.3) | 390 (49.4) |
Angiotensin-converting enzyme inhibitors/angiotensinb receptor blockers | 815 (49.2) | 425 (49.0) | 390 (49.4) |
β-blockers, α/β-blockers | 93 (5.6) | 43 (5.0) | 50 (6.3) |
Diuretics | 79 (4.8) | 46 (5.3) | 33 (4.2) |
Others | 37 (2.2) | 21 (2.4) | 16 (2.0) |
Clopidogrel at randomization | 973 (58.7) | 518 (59.7) | 455 (57.6) |
Stroke subtype | |||
Lacunar | 825 (49.8) | 427 (49.3) | 398 (50.4) |
Atherothrombotic | 717 (43.3) | 375 (43.3) | 342 (43.3) |
Infarct location | |||
Supratentorial (purely) | 1,243 (75.0) | 649 (74.9) | 594 (75.2) |
Infratentorial (purely) | 394 (23.8) | 204 (23.5) | 190 (24.1) |
Both | 20 (1.2) | 14 (1.6) | 6 (0.8) |
Time to randomization after index event, days | 27 [14–63] | 26 [14-62.5] | 27 [14–63] |
Blood pressure levels, mmHg | |||
Baseline, systolic | 139.0 ± 19.7 | 139.9 ± 20.6 | 138.1 ± 18.7 |
Baseline, diastolic | 79.0 ± 13.4 | 79.5 ± 13.4 | 78.5 ± 13.2 |
Mean follow-up, systolic | 136.1 ± 12.6 | 137.1 ± 12.6 | 135.1 ± 12.6 |
Mean follow-up, diastolic | 77.0 ± 9.2 | 77.5 ± 9.2 | 76.5 ± 9.3 |
