Table 1 The bidirectional results between FBS and SBP based on Sensitivity Mendelian Randomization analysis using genetic instrument variables

From: The 14-year cumulative genetic high blood pressure and risk of type 2 diabetes in Korean: observational and Mendelian randomization evidence

 

FBS → SBP

SBP → FBS

(No. of genetic IVs=91)

(No. of genetic IVs=68)

(No. of genetic IVs=67)

      

Without rs671*

Effect size

S.E.

p-value

Effect size

S.E.

p-value

Effect size

S.E.

p-value

IVW†

0.192

0.021

<0.0001

0.569

0.060

<0.0001

0.490

0.056

<0.0001

Simple median†

0.142

0.024

<0.0001

0.354

0.061

<0.0001

0.353

0.061

<0.0001

Weighted median†

0.091

0.023

<0.0001

0.376

0.062

<0.0001

0.327

0.056

<0.0001

MR-egger†

0.204

0.057

<0.0001

1.078

0.157

<0.0001

0.722

0.188

<0.0001

(Intercept)

−0.009

0.039

0.8230

−0.226

0.065

0.0010

−0.097

0.075

0.1960

  1. FBS fasting blood sugar, SBP systolic blood pressure, IV instrument variant, S.E. standard error, IVW inverse variance weighted, MR mendelian randomization
  2. *The only one overlapped instrumented variant in both directions
  3. †Effect (S.E.) per genetically determined FBS value (mg/dL) 1-SD increasing or SBP value (mmHg) 1-SD increasing; Due to the characteristics of genetic data in Korea, the FBS value in mg/dL units was used for these analyses
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