Table 2 Association between trajectories and subsequence hypertension or Type 2 diabetes incidents based on Cox proportional-hazards model

From: The 14-year cumulative genetic high blood pressure and risk of type 2 diabetes in Korean: observational and Mendelian randomization evidence

  

No. of Persons

No. of HTN

Person years, follow-up

HTN incidence Rate per 1000 P (95%CI)

 

HTN

 

Model 1a

Model 2b

Model 2c

HR (95% CI)

HR (95% CI)

HR (95% CI)

FBS trajectory groups

Controlled

6099

4152

53397.88

77.76 (75.41–80.16)

1.0

1.0

1.0

Uncontrolled

179

171

1235.12

144.93 (124.47–167.78)

1.77 (1.52–2.07)

1.78 (1.52–2.07)

1.06 (0.91–1.24)

−2 LOG L

    

71,202.219

71,193.789

70,283.752

  

No. of Persons

No. of T2D

Person years, follow-up

T2D incidence Rate per 1000 P (95%CI)

T2D

 

Model 1a

Model 2b

Model 2c

 

HR (95% CI)

HR (95% CI)

HR (95% CI)

SBP trajectory groups

Controlled

6193

3160

54,323.70

58.17 (56.16–60.23)

1.0

1.0

1.0

 

Uncontrolled

85

60

309.30

193.99 (148.03–249.70)

1.77 (1.32–2.00)

1.71 (1.32–2.20)

1.25 (1.00–1.58)

 

−2 LOG L

    

53,722.472

53,710.758

52,246.293

  1. FBS fasting blood sugar, SBP systolic blood pressure, HR hazard ratio, T2D type 2 diabetes
  2. Bold values denote significant values
  3. aadjusted for age and sex
  4. badjusted for age, sex, BMI, smoking behavior, alcohol drink, exercise, and antidiabetic or antihypertensive medications
  5. cadjusted for age, sex, BMI, smoking behavior, alcohol drink, exercise, antidiabetic or antihypertensive medications, and baseline polygenic risk score quartiles
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