Table 2 Regression coefficients (standard error) and significance (p-value) (before, p, and after FDR correction, pFDR) of the hypertension status, HbA1c or age vs. relaxometry metrics (MWF, R1 and R2) derived from the logistic regression analysis

From: Investigating the association between human brainstem microstructural integrity and hypertension using magnetic resonance relaxometry

 

MWF

HbA1c

Age

R1

HbA1c

Age

R2

HbA1c

Age

SCP

−0.34(0.32),

p = 0.289

pFDR = 0.311

0.42(0.28),

p = 0.133

pFDR = 0.189

1.16(0.34),

p < 0.001

pFDR < 0.001

−0.40(0.29),

p = 0.162

pFDR = 0.226

0.36(0.29),

p = 0.210

pFDR = 0.274

1.20(0.33),

p < 0.001

pFDR < 0.001

−0.43(0.32),

p = 0.184

pFDR = 0.448

0.33(0.29),

p = 0.256

pFDR = 0.256

1.17(0.33)

p < 0.001

pFDR = 0.001

MCP

−0.61(0.32),

p = 0.057

pFDR = 0.160

0.38(0.28),

p = 0.176

pFDR = 0.189

1.25(0.33),

p < 0.001

pFDR < 0.001

−0.46(0.29),

p = 0.112

pFDR = 0.223

0.34(0.28),

p = 0.224

pFDR = 0.274

1.26(0.33),

p < 0.001

pFDR < 0.001

−0.36(0.30),

p = 0.226

pFDR = 0.452

0.43(0.28),

p = 0.131

pFDR = 0.213

1.18(0.33),

p < 0.001

pFDR = 0.001

ICP

−0.32(0.29),

p = 0.264

pFDR = 0.308

0.38(0.28),

p = 0.170

pFDR = 0.189

1.18(0.34),

p < 0.001

pFDR < 0.001

−0.46(0.29),

p = 0.112

pFDR = 0.223

0.34(0.29),

p = 0.235

pFDR = 0.274

1.20(0.33),

p < 0.001

pFDR < 0.001

−0.10(0.28),

p = 0.710

pFDR = 0.828

0.36(0.28),

p = 0.198

pFDR = 0.213

1.20(0.34),

p < 0.001

pFDR = 0.001

CP

−0.33(0.28),

p = 0.232

pFDR = 0.296

0.39(0.28),

p = 0.163

pFDR = 0.189

1.20(0.33),

p < 0.001

pFDR < 0.001

−0.41(0.28),

p = 0.136

pFDR = 0.223

0.34(0.29),

p = 0.233

pFDR = 0.274

1.26(0.33),

p < 0.001

pFDR < 0.001

−0.22(0.29),

p = 0.437

pFDR = 0.664

0.39(0.28),

p = 0.169

pFDR = 0.213

1.13(0.35),

p = 0.001

pFDR = 0.002

MED

−0.77(0.38),

p = 0.040

pFDR = 0.141

0.50(0.28),

p = 0.076

pFDR = 0.189

1.19(0.33),

p < 0.001

pFDR < 0.001

−0.59(0.30),

p = 0.052

pFDR = 0.183

0.31(0.29),

p = 0.281

pFDR = 0.281

1.11(0.33),

p < 0.001

pFDR < 0.001

−0.52(0.36),

p = 0.154

pFDR = 0.448

0.41(0.29),

p = 0.161

pFDR = 0.213

0.97(0.37),

p = 0.008

pFDR = 0.010

MID

−0.76(0.34),

p = 0.028

pFDR = 0.223

0.50(0.29),

p = 0.086

pFDR = 0.189

0.97(0.34),

p = 0.004

pFDR = 0.005

−0.64(0.31),

p = 0.038

pFDR = 0.123

0.38(0.29),

p = 0.189

pFDR = 0.274

1.03(0.33),

p = 0.001

pFDR = 0.001

-1.24(0.52),

p = 0.018

pFDR = 0.123

0.45(0.30),

p = 0.136

pFDR = 0.213

0.47(0.41),

p = 0.259

pFDR = 0.259

PON

−0.46(0.31),

p = 0.143

pFDR = 0.223

0.41(0.27),

p = 0.131

pFDR = 0.189

1.16(0.33),

p < 0.001

pFDR < 0.001

−0.43(0.29),

p = 0.143

pFDR = 0.223

0.32(0.28),

p = 0.261

pFDR = 0.281

1.21(0.33),

p < 0.001

pFDR < 0.001

−0.25(0.34),

p = 0.474

pFDR = 0.664

0.40(0.28),

p = 0.150

pFDR = 0.213

1.12(0.36),

p = 0.002

pFDR = 0.003

RN

−0.89(0.33),

p = 0.007

pFDR = 0.092

0.53(0.29),

p = 0.068

pFDR = 0.189

0.95(0.34),

p = 0.005

pFDR = 0.005

−0.76(0.31),

p = 0.015

pFDR = 0.155

0.38(0.30),

p = 0.206

pFDR = 0.274

1.08(0.33),

p = 0.001

pFDR < 0.001

−0.92(0.34),

p = 0.006

pFDR = 0.090

0.50(0.29),

p = 0.085

pFDR = 0.213

0.77(0.34),

p = 0.025

pFDR = 0.027

SN

−0.52(0.31),

p = 0.096

pFDR = 0.189

0.47(0.29),

p = 0.103

pFDR = 0.189

1.11(0.33),

p < 0.001

pFDR = 0.001

−0.53(0.29),

p = 0.066

pFDR = 0.185

0.37(0.28),

p = 0.196

pFDR = 0.274

1.24(0.33),

p < 0.001

pFDR < 0.001

−0.56(0.31),

p = 0.070

pFDR = 0.328

0.47(0.30),

p = 0.114

pFDR = 0.213

1.10(0.34),

p = 0.001

pFDR = 0.002

STH

−0.65(0.31),

p = 0.034

pFDR = 0.141

0.45(0.31),

p = 0.144

pFDR = 0.189

1.10(0.33),

p < 0.001

pFDR = 0.001

−0.20(0.27),

p = 0.452

pFDR = 0.452

0.37(0.28),

p = 0.185

pFDR = 0.274

1.25(0.33),

p < 0.001

pFDR < 0.001

0.04(0.25),

p = 0.858

pFDR = 0.858

0.37(0.28),

p = 0.185

pFDR = 0.213

1.25(0.33),

p < 0.001

pFDR = 0.001

  1. Results are shown for the 10 brainstem subregions investigated. Bolded p-values indicate statistical significance (p < 0.05) or close-to-significance (p < 0.1)
  2. HbA1c hemoglobin A1c, MWF myelin water fraction, R1 Longitudinal relaxation rate, R2 Transverse relaxation rate, ROIs regions-of-interest, SCP superior cerebellar peduncle, MCP middle cerebellar peduncle, ICP inferior cerebellar peduncle, CP cerebral peduncle, MED medulla, MID midbrain, PON pons, RN red nucleus, SN substantia nigra, STH subthalamic nucleus
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