Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Mini Review
  • Mini review series: Current topic in Hypertension 2024
  • Published:

Hypertension research 2024 update and perspectives: blood pressure management

Hypertension Research volume 48, pages 1733–1738 (2025)Cite this article

Abstract

This mini-review article presents a comprehensive update on recent advancements in blood pressure management, based on original research published between 2023 and 2024. As part of the “Hypertension Research 2024 Update and Perspectives”, the review integrates insights from the JSH2024 Fukuoka Declaration, emphasizing the concept of “NEO-HYPERTENSION harmonized with society”. The strategies proposed in this review aim to realize this concept by promoting lifelong blood pressure management, preemptive medicine, and leveraging digital health technologies. Key strategies include adherence to treatment guidelines, overcoming clinical inertia, and the utilization of new digital tools and novel antihypertensive agents. Additionally, the review explores the significance of multidisciplinary collaboration and non-pharmacological therapies, as well as the importance of setting individualized treatment goals tailored to patients’ unique backgrounds. By aligning with the JSH’s vision, this review offers a fresh perspective on contemporary clinical practices and future directions. These updates aim to contribute to improved patient outcomes and global health advancements in hypertension care.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1

Similar content being viewed by others

References

  1. Node K, Tanaka A, Nishiyama A, Kario K. JSH2024 Fukuoka Declaration “NEO-HYPERTENSION harmonized with society”. Hypertens Res. 2024;47:3287.

    Article  PubMed  Google Scholar 

  2. Wang TD, Ohkubo T, Bunyi ML, Chadachan VM, Chia YC, Kario K, et al. Current realities of home blood pressure monitoring from physicians’ perspectives: results from Asia HBPM survey 2020. Hypertens Res 2023;46:1638–49.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Umishio W, Ikaga T, Kario K, Fujino Y, Suzuki M, Ando S, et al. Role of housing in blood pressure control: a review of evidence from the Smart Wellness Housing survey in Japan. Hypertens Res. 2023;46:9–18.

    Article  PubMed  Google Scholar 

  4. Collaboration NCDRF. Long-term and recent trends in hypertension awareness, treatment, and control in 12 high-income countries: an analysis of 123 nationally representative surveys. Lancet 2019;394:639–51.

    Article  Google Scholar 

  5. Collaboration NCDRF. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet 2021;398:957–80.

    Article  Google Scholar 

  6. Sakima A, Yamazato M, Kohagura K, Ishida A, Matayoshi T, Tana T, et al. Achievement rate of target blood pressure in patients with hypertension treated by hypertension specialists and non-specialists in a real-world setting. Hypertens Res. 2023. https://doi.org/10.1038/s41440-023-01362-3.

  7. He J, Ouyang N, Guo X, Sun G, Li Z, Mu J, et al. Effectiveness of a non-physician community health-care provider-led intensive blood pressure intervention versus usual care on cardiovascular disease (CRHCP): an open-label, blinded-endpoint, cluster-randomised trial. Lancet. 2023;401:928–38.

    Article  PubMed  Google Scholar 

  8. Neal B, Wu Y, Feng X, Zhang R, Zhang Y, Shi J, et al. Effect of Salt Substitution on Cardiovascular Events and Death. N Engl J Med. 2021;385:1067–77.

    Article  CAS  PubMed  Google Scholar 

  9. Yuan Y, Jin A, Neal B, Feng X, Qiao Q, Wang H, et al. Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial. Nat Med. 2023;29:973–81.

    Article  CAS  PubMed  Google Scholar 

  10. Zhang X, Yuan Y, Li C, Feng X, Wang H, Qiao Q, et al. Effect of a Salt Substitute on Incidence of Hypertension and Hypotension Among Normotensive Adults. J Am Coll Cardiol. 2024;83:711–22.

    Article  CAS  PubMed  Google Scholar 

  11. Kaya E, Solak Y, Sahin M, Kurt B, Vural Solak GT, Ucer H. Is YouTube useful as a source of information for approaches to reducing blood pressure and hypertension treatment? Hypertens Res. 2023;46:386–94.

    Article  PubMed  Google Scholar 

  12. Kario K, Nomura A, Harada N, Okura A, Nakagawa K, Tanigawa T, et al. Efficacy of a digital therapeutics system in the management of essential hypertension: the HERB-DH1 pivotal trial. Eur Heart J. 2021;42:4111–22.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Kario K, Tomitani N, Harada N, Okura A, Hisaki F, Tanigawa T, et al. Home blood pressure-lowering effect of digital therapeutics in hypertension: impact of body weight and salt intake. Hypertens Res. 2023. https://doi.org/10.1038/s41440-023-01245-7.

  14. Hisaki F, Aga M, Tomitani N, Okawara Y, Harada N, Kario K. Daily self-reported behavioural efficacy records on hypertension digital therapeutics as digital metrics associated with the reduction in morning home blood pressure: post-hoc analysis of HERB-DH1 trial. Hypertens Res. 2023. https://doi.org/10.1038/s41440-023-01434-4.

  15. Nozato Y, Yamamoto K. The effects of smartphone apps expected in self-management for hypertension management. Hypertens Res. 2024;47:564–5.

    Article  PubMed  Google Scholar 

  16. Han M, Lee YR, Park T, Ihm SH, Pyun WB, Burkard T, et al. Feasibility and measurement stability of smartwatch-based cuffless blood pressure monitoring: A real-world prospective observational study. Hypertens Res. 2023;46:922–31.

    Article  PubMed  Google Scholar 

  17. Kario K, Williams B, Tomitani N, McManus RJ, Schutte AE, Avolio A, et al. Innovations in blood pressure measurement and reporting technology: International Society of Hypertension position paper endorsed by the World Hypertension League, European Society of Hypertension, Asian Pacific Society of Hypertension, and Latin American Society of Hypertension. J Hypertens. 2024;42:1874–88.

    Article  CAS  PubMed  Google Scholar 

  18. Freeman MW, Halvorsen YD, Marshall W, Pater M, Isaacsohn J, Pearce C, et al. Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension. N Engl J Med. 2023;388:395–405.

    Article  CAS  PubMed  Google Scholar 

  19. Desai AS, Webb DJ, Taubel J, Casey S, Cheng Y, Robbie GJ, et al. Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension. N Engl J Med. 2023;389:228–38.

    Article  CAS  PubMed  Google Scholar 

  20. Bakris GL, Saxena M, Gupta A, Chalhoub F, Lee J, Stiglitz D, et al. RNA Interference With Zilebesiran for Mild to Moderate Hypertension: The KARDIA-1 Randomized Clinical Trial. JAMA 2024;331:740–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Pickersgill SJ, Msemburi WT, Cobb L, Ide N, Moran AE, Su Y, et al. Modeling global 80-80-80 blood pressure targets and cardiovascular outcomes. Nat Med. 2022;28:1693–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Liu J, Li Y, Ge J, Yan X, Zhang H, Zheng X, et al. Lowering systolic blood pressure to less than 120mm Hg versus less than 140mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial. Lancet 2024;404:245–55.

    Article  PubMed  Google Scholar 

  23. Liu X, Steinman MA, Lee SJ, Peralta CA, Graham LA, Li Y, et al. Systolic blood pressure, antihypertensive treatment, and cardiovascular and mortality risk in VA nursing home residents. J Am Geriatr Soc. 2023;71:2131–40.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Yoichi Nozato

Authors
  1. Yoichi Nozato
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Yoichi Nozato.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nozato, Y. Hypertension research 2024 update and perspectives: blood pressure management. Hypertens Res 48, 1733–1738 (2025). https://doi.org/10.1038/s41440-025-02130-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41440-025-02130-1

Keywords

This article is cited by

Search

Advanced search

Quick links