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References
Bunag RD, Tomita T, Sasaki S. Chronic sucrose ingestion induces mild hypertension and tachycardia in rats. Hypertension. 1983;5:218–25.
Schiano C, Grimaldi V, Boccella S, Iannotta M, Zullo A, Luongo L, et al. Sweeteners modulate bioactivity of endothelial progenitor cells but not induce detrimental effects both on inflammation and behavioural changes. Int J Food Sci Nutr. 2019;70:725–37.
Borresen KO, Rosendahl-Riise H, Brantsaeter AL, Egeland GM. Intake of sucrose-sweetened beverages and risk of developing pharmacologically treated hypertension in women: cohort study. BMJ Nutr Prev Health. 2022;5:277–85.
Cao D, Lu H, Lewis TL, Li L. Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease. J Biol Chem. 2007;282:36275–82.
Farah V, Elased KM, Chen Y, Key MP, Cunha TS, Irigoyen MC, et al. Nocturnal hypertension in mice consuming a high fructose diet. Auton Neurosci. 2006;130:41–50.
Forrester SJ, Booz GW, Sigmund CD, Coffman TM, Kawai T, Rizzo V, et al. Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology. Physiological reviews. 2018;98:1627–738.
Monnard CR, Grasser EK. Perspective: cardiovascular responses to sugar-sweetened beverages in humans: a narrative review with potential hemodynamic mechanisms. Adv Nutr. 2018;9:70–7.
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The study was supported by a grant (HL174004) from National Institute of Health.
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Nakayama, Y., Utsunomiya, H., Eguchi, K. et al. A mouse model of hypertension induced by sucrose. Hypertens Res 48, 2475–2477 (2025). https://doi.org/10.1038/s41440-025-02278-w
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DOI: https://doi.org/10.1038/s41440-025-02278-w