Fig. 2

Effect of intensive BP lowering on risk of cardiovascular events and severe adverse effects in patients with hypertension aged ≥ 75 years. a Composite cardiovascular events, b all-cause mortality, c cardiovascular death, d stroke, and e severe adverse events. Boxes and horizontal lines represent risk ratio (RR) and 95% confidence interval (CI) for each trial. The size of boxes is proportional to the weight of that trial result. Diamonds represent 95% CI for pooled estimates of effect and are centered on pooled RR