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Redefining hyperuricemia in chronic kidney disease: a focus on tubulo-glomerular urate handling

Hypertension Research volume 48, pages 2766–2767 (2025)Cite this article

Scheme of a proposed classification of hyperuricemia. A proposed scheme of hyperuricemia integrating renal uric acid handling. Renal underexcretion type can occur due to reduced glomerular filtration rate (glomerular under-filtration type) or increased reabsorption of urate in the renal tubules (tubular over-reabsorption type).

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References

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Authors and Affiliations

  1. Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Yonago, Japan

    Tomoaki Takata, Yukari Mae, Shotaro Hoi & Hajime Isomoto

  2. Matsue City Hospital, Matsue, Japan

    Ichiro Hisatome

  3. NHO Yonago Medical Center, Yonago, Japan

    Ichiro Hisatome

Authors
  1. Tomoaki Takata
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  2. Yukari Mae
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  3. Shotaro Hoi
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  4. Ichiro Hisatome
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  5. Hajime Isomoto
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Correspondence to Tomoaki Takata.

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Takata, T., Mae, Y., Hoi, S. et al. Redefining hyperuricemia in chronic kidney disease: a focus on tubulo-glomerular urate handling. Hypertens Res 48, 2766–2767 (2025). https://doi.org/10.1038/s41440-025-02311-y

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  • DOI: https://doi.org/10.1038/s41440-025-02311-y

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