Table 4 Multivariable analysis of relationships of FMD and NID with variables

From: Relationship of TMAO levels with vascular function in patients with hypertension

Variables

FMD

NID

β

VIF

t value

P value

β

VIF

t value

P value

Age, year

−0.22

1.83

−2.68

<0.01

−0.28

1.82

−3.36

<0.01

Body mass index, kg/m2

−0.09

1.27

−1.30

0.20

−0.16

1.38

−2.27

0.02

Heart rate, bpm

0.07

1.21

1.00

0.32

0.04

1.21

0.61

0.54

Systolic blood pressure, mmHg

0.19

1.30

2.79

<0.01

0.03

1.31

0.42

0.67

Triglycerides, mg/dL

−0.03

1.40

−0.41

0.68

−0.04

1.38

−0.60

0.55

HDL-C, mg/dL

<0.01

1.66

0.00

1.00

0.08

1.66

1.08

0.28

Total cholesterol, mg/dL

−0.03

1.46

−0.03

0.70

0.03

1.47

0.41

0.69

eGFR, mL/min/1.73m2

−0.02

1.42

−0.25

0.81

<0.01

1.42

0.01

1.00

Hemoglobin A1c, %

−0.14

1.57

−1.90

0.06

−0.06

1.57

−0.75

0.45

Men

−0.09

1.27

−1.30

0.20

0.04

1.27

0.57

0.57

Three or more kinds of antihypertensive drugs

−0.01

1.18

−0.15

0.88

<0.01

1.18

0.04

0.96

Lipid-lowering drug treatment

0.08

1.47

1.13

0.26

−0.01

1.46

−0.09

0.93

Antidiabetic drug treatment

−0.06

1.64

−0.77

0.44

−0.06

1.64

−0.75

0.45

Past CVD

0.10

1.44

1.31

0.19

0.17

1.45

−2.38

0.02

Current smoking

−0.03

1.18

0.47

0.64

0.06

1.17

0.97

0.33

Log TMAO

−0.04

1.23

−0.63

0.53

<0.01

1.18

−0.04

0.96

  1. The adjusted r2 was 0.21 in FMD and 0.18 in NID
  2. FMD flow-mediated vasodilation, NID nitroglycerine-induced vasodilation, HDL-C high-density lipoprotein cholesterol, eGFR estimated glomerular filtration rate, CVD cardiovascular disease, TMAO trimethylamine-N-oxide