Fig. 4 | Hypertension Research

Fig. 4

From: Goreisan attenuates cardiac hypertrophy and diastolic dysfunction in heart failure with preserved ejection fraction induced by HFD/L-NAME via regulation of ICAT-β-catenin/ERK axis

Fig. 4

ICAT and β-catenin were involved in the protective effects of GRS against HFpEF hearts. A Volcano blots of the different expressed proteins (DEPs) in HFD/L-NAME to control. #1 indicates 199 proteins increased in HFD/L-NAME compared to control. #2 indicates 99 proteins decreased in HFD/L-NAME compared with control. B Volcano blots of DEPs in HFD/L-NAME + GRS to HFD/L-NAME. #3 indicates 91 proteins increased in HFD/L-NAME + GRS compared with HFD/L-NAME. #4 indicates 111 proteins decreased in HFD/L-NAME + GRS compared with HFD/L-NAME. C Selection of proteins decreased by HFD/L-NAME and increased by GRS. D Representative immunoblots and quantitative analysis of ICAT, β-catenin, and GAPDH in hearts of the indicated groups (n = 5–8). *P < 0.05, **P < 0.01: post-hoc Tukey’s comparison test

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