Table 2 Asians vs Caucasians for stroke thrombolysis: results from a meta-analysis
From: Development of tenecteplase for stroke thrombolysis: Japan’s endeavor
Outcome | Studies | Risk ratio (95% confidence interval) | I2 (%) | 95% prediction interval | P (for subgroup differences) |
|---|---|---|---|---|---|
Complete recanalization | |||||
Asian | 4 | 1.91 (1.30–2.80) | 62 | 0.82–4.43 | <0.01 |
Caucasian | 10 | 0.99 (0.87–1.14) | 78 | 0.35–4.02 | |
Early neurological improvement | |||||
Asian | 4 | 1.02 (0.92–1.13) | 70 | 0.33–4.50 | 0.48 |
Caucasian | 8 | 1.07 (0.98–1.18) | 69 | 0.61–3.04 | |
Modified Rankin scale 0–2 | |||||
Asian | 8 | 1.00 (0.95–1.05) | 58 | 0.94–1.06 | <0.01 |
Caucasian | 10 | 1.14 (1.10–1.19) | 48 | 0.99–1.35 | |
Modified Rankin scale 0–1 | |||||
Asian | 3 | 1.07 (0.99–1.15) | 0 | 0.94–1.21 | 0.27 |
Caucasian | 12 | 1.12 (1.07–1.17) | 55 | 0.87–1.34 | |
Mortality | |||||
Asian | 7 | 1.18 (0.87–1.62) | 21 | 0.81–1.73 | 0.01 |
Caucasian | 15 | 1.10 (1.00–1.22) | 68 | 0.45–2.06 | |
Mixed | 5 | 0.89 (0.79–1.00) | 45 | 0.60–1.35 | |
Symptomatic intracranial hemorrhage | |||||
Asian | 8 | 1.06 (0.71–1.56) | 0 | 0.67–1.68 | 0.20 |
Caucasian | 16 | 0.83 (0.66–1.04) | 45 | 0.41–2.66 | |
Mixed | 4 | 0.53 (0.28–1.01) | 0 | 0.13–2.18 | |
Any intracranial hemorrhage | |||||
Asian | 7 | 0.99 (0.76–1.31) | 38 | 0.46–2.42 | 0.83 |
Caucasian | 7 | 1.00 (0.86–1.17) | 44 | 0.83–1.21 | |
Mixed | 3 | 1.08 (0.88–1.34) | 0 | 0.27–4.31 | |
