Fig. 3
Heterogeneity of trophoblast cells in control and preeclampsia. A A total of three major trophoblast cell types were identified. B The proportion of identified trophoblast cell types in the placentas. C Inference of pseudotime trajectories for trophoblast cells, color-coded according to cell subsets. D Gene Ontology (GO) analysis of extravillous trophoblast (EVT) cells between EOPE and preterm group. E GO analysis of cytotrophoblast (CTB) cells between EOPE and preterm group. F The expression of HIF-1 in various placental cells between EOPE and preterm group. G GO analysis of EVT cells between LOPE and term group. H GO analysis of CTB cells between LOPE and term group. I The expression of gene related to extracellular region in various placental cells between EOPE and preterm group. EOPE early-onset preeclampsia, LOPE late-onset preeclampsia, CTB cytotrophoblast, EVT extravillous trophoblast, STB syncytiotrophoblast, HB Hofbauer cells. ***, P < 0.001; ****, P < 0.0001; ns not significant
