Extended Data Fig. 10: Different effects of BAS, SAS and MAS mutations on chromatin accessibility.

a, Heatmap depicting the effects of BAS, SAS, and MAS enzyme mutations on chromatin accessibility at genes whose chromatin accessibility is specifically reduced in brm, syd, and minu1/2. WT: wild type. b, Boxplots showing the chromatin accessibility levels in the brm, syd and minu1/2 mutants and the wild type at the 400~1500 bp upstream region of TSS and at the −400~200-bp TSS-flanking region. Those genes with reduced chromatin accessibility specifically in brm, syd, and minu1/2 mutants were independently analyzed. In box plots, center lines and box edges are medians and the interquartile range (IQR), respectively. Whiskers extend within 1.5 times the IQR. P values determined by two-tailed Wilcoxon signed rank test indicate the difference between the mutants and the wild-type control. WT: wild type. P values of reduced and increased signals in indicated mutants are shown in blue and red, respectively.