Fig. 4: Targeted gene silencing by HDACs and histone deacetylation.
From: A gene silencing screen uncovers diverse tools for targeted gene repression in Arabidopsis
a, Screenshots of histone H3K9ac, H3K27ac, H4K16ac and H3 ChIP–seq signals over FWA region in fwa, HD2A-ZF, HD2B-ZF and HD2C-ZF. b–d, Heat maps and metaplots representing the normalized H3K9ac (b), H3K27ac (c) and H4K16ac (d) ChIP–seq signals over ZF off-target sites and the shuffled sites (n = 6,091) in the representative T2 lines of HD2A-ZF, HD2B-ZF and HD2C-ZF versus fwa. e, Screenshots of histone H3K9ac, H3K14ac and H3 ChIP–seq signals over FWA region in fwa, HDA6-ZF and MSI1-ZF. f, Heat maps and metaplots representing the normalized H3K9ac and H3K14ac ChIP–seq signals over ZF off-target sites and the shuffled sites (n = 6,091) in HDA6-ZF and MSI1-ZF T2 representative lines versus fwa.
