Injury-induced regeneration allows plants to restore lost or damaged cells, tissues and organs and thus to survive severe injuries. A recent study shows that the microRNA396–GROWTH REGULATING FACTORs (miR396–GRFs) module has a bifunctional role in restoring a damaged root: miR396 bolsters regeneration potential, while its targets, the GRFs, accelerate regeneration speed.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Ikeuchi, M. et al. Annu. Rev. Plant Biol. 70, 377–406 (2019).
Xu, J. et al. Science 311, 385–388 (2006).
Durgaprasad, K. et al. Cell Rep. 29, 453–463.e3 (2019).
Marhava, P. et al. Cell 177, 957–969.e13 (2019).
Zhou, W. et al. Cell 177, 942–956.e14 (2019).
Rodriguez, R. E. et al. Plant Cell 27, 3354–3366 (2015).
Debernardi, J. M. et al. Nat. Biotechnol. 38, 1274–1279 (2020).
Kong, J. et al. Front. Plant Sci. 11, 572319 (2020).
Baulies, J. L. et al. Nat. Plants https://doi.org/10.1038/s41477-025-01922-0 (2025).
Hoermayer, L. et al. Proc. Natl Acad. Sci. USA 117, 15322–15331 (2020).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Hu, Z., Han, H. & Wang, G. A microRNA defines root regeneration. Nat. Plants 11, 387–388 (2025). https://doi.org/10.1038/s41477-025-01928-8
Published:
Version of record:
Issue date:
DOI: https://doi.org/10.1038/s41477-025-01928-8
