Extended Data Fig. 1: Structural comparison of individual domains among sNSV polymerases. | Nature Plants

Extended Data Fig. 1: Structural comparison of individual domains among sNSV polymerases.

From: Structural basis for the activation of plant bunyavirus replication machinery and its dual-targeted inhibition by ribavirin

Extended Data Fig. 1: Structural comparison of individual domains among sNSV polymerases.

Viral polymerases with complete structure including TSWV L, LACV L (PDB ID: 6Z6G), SFTSV L (PDB ID: 6L42), LASV L (PDB ID: 7OJN) and FluA polymerase (PDB ID: 4WSB) are shown as ribbon. PA-like (upper panel), PB1-like (middle panel) and PB2-like (lower panel) domain between these polymerases all share a similar overall architecture. For TSWV L, more α-helix structures than other polymerases are present in the endo region and α-ribbon region, respectively. The separated regions in PB2-like domain are relatively variable, except for the structurally conserved CBD region.

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