Extended Data Fig. 3: In vitro kinase activity assays of CDKL9 and GTE7.

a. The protein structure of CDKL9 was predicted by AlphaFold3. Potential ATP binding sites (196-205) were zoomed in by dashed box. b. In vitro kinase assay of CDKL9 on GTE7. c. In vitro kinase assay of GTE7 on Pol II CTD. The experiments in b and c were repeated independently two times and showed similar results.