Shahzad et al. show that heritable changes in gene body methylation shape phenotypic diversity in Arabidopsis thaliana, adding an epigenetic layer to the evolutionary mechanisms that plants use to adapt to their environment.
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References
Shahzad, Z. et al. Nat. Plants https://doi.org/10.1038/s41477-025-02108-4 (2025).
Schmitz, R. J., Lewis, Z. A. & Goll, M. G. Trends Genet. 35, 818–827 (2019).
Kawashima, T. & Berger, F. Nat. Rev. Genet. 15, 613–624 (2014).
van der Graaf, A. et al. Proc. Natl Acad. Sci. USA 112, 6676–6681 (2015).
Briffa, A. et al. Cell Syst. 14, 953–967.e17 (2023).
Muyle, A., Seymour, D. K., Lv, Y., Huettel, B. & Gaut, B. S. Genome Biol. Evol. 14, evac038 (2022).
Muyle, A. & Gaut, B. S. Mol. Biol. Evol. 36, 155–158 (2019).
Vojta, A. et al. Nucleic Acids Res. 44, 5615–5628 (2016).
Lamarck, J.-B. Philosophie Zoologique, ou Exposition des Considérations Relatives à l’Histoire Naturelle des Animaux (Dentu, Libraire, 1809).
Muyle, A., Ross-Ibarra, J., Seymour, D. K. & Gaut, B. S. Genetics 218, iyab061 (2021).
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Muyle, A. Adaptation beyond the DNA sequence. Nat. Plants 11, 1987–1988 (2025). https://doi.org/10.1038/s41477-025-02116-4
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DOI: https://doi.org/10.1038/s41477-025-02116-4