Extended Data Fig. 9: MAIL1/MAIN and MAIL2 pathways target distinct sets of genes. | Nature Plants

Extended Data Fig. 9: MAIL1/MAIN and MAIL2 pathways target distinct sets of genes.

From: Plant mobile domain protein–DNA motif modules counteract Polycomb silencing to stabilize gene expression

Extended Data Fig. 9

(a) Venn diagrams showing no overlap between mail1- and amiR-mail2- downregulated genes. (b) Developmental phenotypes observed upon MAIL2 depletion in mail1 mutant background. Scheme of the cross is illustrated with photos of two-week-old plants. Scale bar is 1 cm. Zoomed-in pictures of mail1 F2 progeny expressing or not the amiR-MAIL2 transgene are shown. (c) Metagene plots (top) and heatmaps (bottom) illustrating MAIL2 enrichment at PCGs that display enhanced H3K27me3 levels in amiR-mail2 mutants (d) Metagene plots (top) and heatmaps (bottom) illustrating TRBs (data from30) and MAIL2 enrichment at MAIL2-associated promoter genes downregulated in amiRNA-mail2 lines. For TRBs, only TRB1 data were represented on the heatmap. (e)Venn Diagram showing overlap between MAIL2 and TRB1 peaks at proximal promoter region of amiRNA-mail2 downregulated genes. (f) Venn diagrams showing overlap of M1M and M2M loci with MAIL1 and MAIL2 peaks respectively.

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