Extended Data Fig. 10: Predicted DNA-binding potential of the PMD-C domains of MAIN, MAIL1 and MAIL2.

(a) Predicted structures of MAIN, MAIL1 and MAIL2 PMD-C domains, with DNA-binding residues mapped onto each structure and colored according to their prediction score. Full length proteins are shown above. (b) Close-up views of the indicated PMD-C regions. DNA-binding residues with a prediction confidence score ≥ 0.8 are colored as in (a). Positively charged residues with a confidence score ≥ 0.8 are highlighted in green. A complete list of DNA-binding prediction scores for amino acid residues of MAIN, MAIL1 and MAIL2 is reported in Supplementary Table 5.