Fig. 1: J147 prevents age-induced transcriptomic changes in Ca2+-related signaling pathways in SAMP8 mouse hippocampus.
From: Targeting of intracellular Ca2+ stores as a therapeutic strategy against age-related neurotoxicities
Boxplot of estimated expression fold changes for the leading edge genes as defined by GSEA for (a) metal ion transporter genes and (b) transporter complex genes. Equivalent numbers of randomly sampled genes from the genome were used as controls. Boxplot center line represents the median, box lower bounds and upper bounds represent the 25th and 75th percentile of the dataset, respectively. Box whiskers reach to data points that are no more than 1.5-fold of the interquartile range of the box. Wilcoxon rank sum test *** p value < 0.001. c, d Corresponding heatmaps of log-transformed gene expression for the leading edge genes. Red = high, blue = low. Treatment groups color-coded at bottom of heatmap; (light gray) left: 9-month control diet (five animals), (dark gray) middle: 13-month control diet (six animals), (red) right: 13-month + J147 diet (six animals).
