Fig. 6: Peroxidative stress test on plasma.
From: Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system
a The Aperoxidative-ratio plot for plasma in baseline (black) and plasma pretreated with hydrogen peroxide (red, green, blue) for non-DM subjects (n = 20), and DM subjects with their glycemic index in good glycemic control (n = 20), and poor glycemic control (n = 52) subgroups. The means and changes in each subgroups were indicated above the box-plots. b A quadrant chart of diabetic subjects stratified into subgroups based on their peroxidative status (normalized Abaseline–Astress) in association with their glycemic levels (e.g., HbA1c). The threshold of Aperoxidative-ratio was set at 75th percentile that of DM subjects with good glycemic control, and adjusting based on clinical needs (e.g., population genetics). Note that the Y-axis (peroxidative stress) is in analogous with Y-axis (nitrosative stress) in quadrant shown in Fig. 4b. The details of quadrant representations are shown in Fig. 1e. The statistical significance was calculated using the Student’s T-test (two-tailed, unequal variance). c The diagnostic accuracies were evaluated using Receiver Operating Characteristic (ROC) for non-DM subjects against DM subjects with good glycemic control (blue) and poor glycemic control (red) subgroups. The number of subjects (n) was indicated on the parentheses.
