Fig. 7: Study design: performance analysis of the proposed markers.
From: Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system
a A cross-sectional, observational study was conducted to evaluate the proposed oxidative stress biomarker against the gold standard (urinary F2-IsoP). Subjects were recruited based on a number of selection (e.g., insulin sensitivity) and exclusion (e.g., smoker) criterion (details in “Methods”). Two distinctive group of subjects established were the insulin-resistant obese subjects (n = 21), and insulin-sensitive lean subjects (n = 21) with demographic as shown in Table 1. The biomarkers evaluated were oxidative stress in red blood cells (the proposed technique), oxidative stress in urine F2-IsoP, and fasting blood glucose.
