Fig. 5: Cross-sectional heatmaps of significantly changed metabolites from heart, serum, and liver in HCR and LCR rats as a function of age. | npj Aging and Mechanisms of Disease

Fig. 5: Cross-sectional heatmaps of significantly changed metabolites from heart, serum, and liver in HCR and LCR rats as a function of age.

From: Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan

Fig. 5

Average heatmaps of significantly changed metabolites from HCR (a) and LCR (b) in the heart at young, 6 months (HCR, n = 8; LCR, n = 8), middle, 17 months (HCR, n = 7; LCR, n = 8), and old, 24 months (HCR, n = 6; LCR, n = 6) age; the liver at young, 6 months (HCR, n = 9; LCR, n = 9), middle, 17 months (HCR, n = 10; LCR, n = 11), and old, 24 months (HCR, n = 9; LCR, n = 8) age; and serum at young, 6 months (HCR, n = 9; LCR, n = 9), middle, 17 months (HCR, n = 8; LCR, n = 8), and old, 24 months (HCR, n = 9; LCR, n = 8) age, ordered according to metabolic pathways. The pseudocolor scale (1 to −1 on the right of the heatmaps) reflects accumulation (red) or depletion (green) for each tissue at each age. See also related Supplementary Figs 11 and 12. c Venn diagrams of the unique and shared significant metabolites from serum and heart-liver of LCR-HCR across ages. The table (bottom) shows the 17 metabolites shared by the heart and liver, independently from strain and age, which were subjected to pathways enrichment analysis. d Bar graph of enriched pathways (p < 0.05) by significant metabolites shared by heart and liver. For analysis details, see “Bioinformatic and statistical analyses” in “Methods”.

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