Fig. 1: Effects of FW1251 and FW1256 on lifespan of WT C. elegans.

a Survival curves and b mean lifespan of WT C. elegans exposed to different doses of FW1251, n = 103–145 animals per condition. c, d Dose–response experiment of FW1256 on lifespan of WT C. elegans, c survival curves, d mean lifespan, n = 111–150 animals per condition. e Boxplot showing distribution of mean lifespan extension effects on WT C. elegans upon exposure to 500 µM of FW1256 from the five independent experiments (Supplementary Table 1). In this box plot, the bottom and top of the box represent the 25% percentile and 75% percentile, the center line represents the median and the whiskers encompass the entire range of values for all five independent experiments. (Survival curves were analyzed using log-rank tests while mean lifespans were analyzed using OASIS2, *p < 0.05, **p < 0.01, ***p < 0.001).