Fig. 2: H2S moiety from FW1256 is the key of longevity increase. | npj Aging and Mechanisms of Disease

Fig. 2: H2S moiety from FW1256 is the key of longevity increase.

From: Lifespan and healthspan benefits of exogenous H2S in C. elegans are independent from effects downstream of eat-2 mutation

Fig. 2

a Confocal microscopy fluorescence images of H2S detection using AzMC (in green) in C. elegans b Fluorescence intensity of the AzMC signal, normalized to body volume of C. elegans (n = 5 animals per condition, t-test, *p < 0.05). c Relative quantification mRNA levels of sqrd-1 and ethe-1 encoding for endogenous H2S detoxification system in WT C. elegans exposed to 500 µM FW1256. Data show expression of sqrd-1 and ethe-1 relative to WT control (n = 3 repeated experiments, one sample t-test, *p < 0.05). d Effect of time-expired FW1256 (500 µM, 4 weeks at room temperature) on lifespan of WT C. elegans (n = 102–163 animals per condition, log-rank tests, ***p < 0.001).

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