Table 1 Quantitative PCR analysis of gene expression in regions of brain tissue from young–adult (4 m) and old (22 m) male mice.

From: Age-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice

Cortex

n

CB1 ± SE

CB2 ± SE

CRIP1 ± SE

FAAH1 ± SE

Young

6

1.00 ± 0.09

1.00 ± 0.04

1.00 ± 0.22

1.00 ± 0.09

Aged

5

0.81 ± 0.13

0.78 ± 0.20

0.63 ± 0.15

0.59 ± 0.09

  

*P = 0.034

P = 0.239

*P = 0.047

*P = 0.002

Hypothalamus

n

CB1 ± SE

CB2 ± SE

CRIP1 ± SE

FAAH1 ± SE

Young

6

1.00 ± 0.24

1.00 ± 0.46

1.00 ± 0.20

1.00 ± 0.17

Aged

5

0.49 ± 1.30

2.55 ± 0.47

1.09 ± 0.71

0.75 ± 1.03

  

P = 0.12

P = 0.06

P = 0.52

P = 0.15

  1. Delta–delta CT was calculated using HPRT as the housekeeping control. Gene expression values for old mice have been normalized to the young group.
  2. *P ≤ 0.05 t test, young vs aged.
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