Fig. 5: Model of TCF1-mediated regulation of miR-181a dependent on GSK3ß. | npj Aging and Mechanisms of Disease

Fig. 5: Model of TCF1-mediated regulation of miR-181a dependent on GSK3ß.

From: The GSK3β-β-catenin-TCF1 pathway improves naive T cell activation in old adults by upregulating miR-181a

Fig. 5

T cell aging is associated with a loss of miR-181a expression due to reduced TCF1 expression (left). Reduced miR-181a expression contributes to impaired T cell function by activating negative regulatory signaling pathways by miR-181a targets, e.g., ERK dephosphorylation by DUSP6. Inhibition of GSK3ß increases the expression of TCF1 and its target miR-181a in T cells from old adults, thus enhancing downstream T cell activation and proliferation (right).

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