Fig. 5: Statistical analyses of age- and HF-associated remodeling of the t-system and RyR clusters. | npj Aging and Mechanisms of Disease

Fig. 5: Statistical analyses of age- and HF-associated remodeling of the t-system and RyR clusters.

From: Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart

Fig. 5: Statistical analyses of age- and HF-associated remodeling of the t-system and RyR clusters.

a Sarcolemmal distances were smaller in cardiomyocytes from donors than HF patients. b Effects of aging on the sarcolemmal distance were small in donors and not significant in HF patients. c The standard deviation of sarcolemmal distances was smaller in cardiomyocytes from donors than HF patients. d Standard deviations of the sarcolemmal distances were affected by age in donors. Effects were not significant in HF patients. e The density of RyR clusters was not different in donors and HF patients. f RyR cluster density was not affected by age. g The distance of RyR clusters to the sarcolemma was smaller in donors than HF patients. h Aging was associated with an increasing sarcolemmal distance of RyR clusters in donor cells. Effects of age on this distance were small in HF patients.

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