Fig. 2: Synteny status of 3p21.31 in major rodent clades. | npj Aging and Mechanisms of Disease

Fig. 2: Synteny status of 3p21.31 in major rodent clades.

From: Convergent evolution of a genomic rearrangement may explain cancer resistance in hystrico- and sciuromorpha rodents

Fig. 2

a Orthologous genomic position of human 3p21.31 genes in myomorphs, sciuromorphs, and hystricomorphs. The positions of PLXNB1, NME6 and CAMP genes are highlighted. PLXNB1-NME6 breakage marks the 3p21.31 split in hystricomorphs and NME6-CAMP breakage marks the split in sciuromorphs. b, c Gain of proximities between TSGs from 3p21.31 and the POGs from 3q21.3/3q27.1 in NMR (b), and from 19p13.21 in alpine marmot (c). Heatmaps represent relative gain and loss of CNVs in the PAN-Cancer cohort normalised to control samples.

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