Fig. 1: Changes in growth rate in the GRZ-AD Nothobranchius furzeri.

a Growth rate of body length in 6-week-, 12-week-, 18-week-, and 24-week-old fish significantly decreases in all age groups. n ≥ 56. b Growth rate of the retinal perimeter, analyzed on mid-sagittal cryosections, significantly declines between 6 weeks and 12 weeks. Thereafter, growth rate does not reduce any further. n ≥ 11. c Also the growth rate of the retinal surface, determined on wholemounts, shows a significant decrease between the age of 6 weeks and 12 weeks. n = 5. d Growth rate of the tectal perimeter, analyzed on coronal cryosections of the central optic tectum, declines upon aging, with a significant reduction between the age of 6 weeks and 12 weeks, and between 18 weeks and 24 weeks. n ≥ 9. e Similar to the tectal perimeter, assessing growth rate of the tectal surface demonstrates a significant drop in growth rate between 6 weeks and 12 weeks, and 18 weeks and 24 weeks of age. n ≥ 8. All data are depicted as mean ± standard error of mean, statistical significance between different age groups is indicated using different letters.