Fig. 2: Gut-brain axis and circadian rhythm association. | npj Aging

Fig. 2: Gut-brain axis and circadian rhythm association.

From: Gut microbiota and circadian rhythm in Alzheimer’s disease pathophysiology: a review and hypothesis on their association

Fig. 2: Gut-brain axis and circadian rhythm association.The alternative text for this image may have been generated using AI.

Aberrant activity of SIRT1, MAPK, and GSK-3 results in altered BMAL1 activity in AD. On the other hand, disruption in BMAL1 activities may contribute to altered IgA secretion and gut microbiota abundance. This process induced Aβ deposition, neuroinflammation, and BBB disruption leading to AD progression. AD Alzheimer’s disease, BMAL1 brain and muscle ARNT-Like 1, GSK-3 glycogen synthase kinase, MAPK mitogen-activated protein kinases, SIRT1 Sirtuin 1.

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