Table 1 Cohort demographics.

From: Unbiased proteomics and multivariable regularized regression techniques identify SMOC1, NOG, APCS, and NTN1 in an Alzheimer’s disease brain proteomic signature

Baltimore longitudinal study of aging (BLSA)

 

Total Sample N = 50

AD N = 31

CN N = 19

Age at death, mean (SD)

86.38 (10.70)†

88.46 (8.30)†

82.98 (13.31)

Age of onset, mean (SD)

-

78.81 (9.92)†

 

Disease duration, mean (SD)

-

9.65 (4.47)†

 

Sex, n (% female)

21 (42.00)†

15 (48.39)†

6 (31.58)

Race, n (% white)

48 (96.00)

31 (100)*

17 (89.47)*

CERAD, mean (SD)

1.78 (1.34)

2.77 (0.43)*

0.16 (0.38)*

Braak, mean (SD)

4.14 (1.69)

5.13 (1.12)*†

2.53 (1.12)*

Religious orders study (ROS)

 

Total Sample N = 53

AD N = 31

CN N = 22

Age at death, mean (SD)

90.58 (6.53)†

92.81 (5.45)*†

87.44 (6.75)*

Age of onset, mean (SD)

-

89.14 (5.71)†

-

Disease duration, mean (SD)

-

3.67 (2.94)†

-

Sex, n (% female)

40 (75.47)†

27 (87.10)*†

13 (59.09)*

Race, n (% white)

53 (100.00)

31 (100.00)

22 (100.00)

CERAD, mean (SD)

1.64 (1.26)

2.58 (0.50)*

0.32 (0.65)*

Braak, mean (SD)

3.89 (1.33)

4.65 (0.66)*†

2.82 (1.30)*

  1. *p < 0.05 comparing AD to CN within a cohort.
  2. †p < 0.05 comparing BLSA to ROS (i.e., AD in BLSA compared to AD in ROS).
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