Table 3 Correlations between plasma sclerostin levels and AD biomarkers among all participants and subgroups stratified by brain Aβ status.

From: Elevated plasma sclerostin is associated with high brain amyloid-β load in cognitively normal older adults

 

All participants

Aβ−

Aβ+

 

ρ

P

ρ

P

ρ

P

NFL

0.337

<0.001

0.445

<0.001

0.095

0.587

GFAP

0.314

0.001

0.218

0.081

0.067

0.703

t-tau

−0.017

0.865

−0.018

0.889

−0.267

0.121

p-tau181

0.393

<0.001

0.279

0.025

0.143

0.434

p-tau231

0.316

0.002

0.241

0.053

0.114

0.541

Aβ42

0.097

0.348

0.217

0.090

0.061

0.737

Aβ40

0.283

0.005

0.336

0.007

0.153

0.395

Aβ42/40

−0.155

0.133

−0.076

0.559

−0.128

0.479

  1. Unadjusted correlation coefficients (ρ) and P values between plasma sclerostin and AD-related biomarkers were calculated using Spearman’s correlation analysis.
  2. P values in bold font were considered as significant (P < 0.05).
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